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2-dehydro-3-deoxy-6-phosphogalactonate aldolase

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2-dehydro-3-deoxy-6-phosphogalactonate aldolase
Identifiers
EC no.4.1.2.21
CAS no.9030-99-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins

The enzyme 2-dehydro-3-deoxy-6-phosphogalactonate aldolase (EC 4.1.2.21) catalyzes the chemical reaction

2-dehydro-3-deoxy-D-galactonate 6-phosphate pyruvate + D-glyceraldehyde 3-phosphate

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming). Other names in common use include 6-phospho-2-keto-3-deoxygalactonate aldolase, phospho-2-keto-3-deoxygalactonate aldolase, 2-keto-3-deoxy-6-phosphogalactonic aldolase, phospho-2-keto-3-deoxygalactonic aldolase, 2-keto-3-deoxy-6-phosphogalactonic acid aldolase, (KDPGal)aldolase, 2-dehydro-3-deoxy-D-galactonate-6-phosphate, and D-glyceraldehyde-3-phosphate-lyase. This enzyme participates in galactose metabolism.

Structural studies

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As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2V81 and 2V82.

References

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  • Shuster CW (1966). "2-Keto-3-deoxy-6-phosphogalactonic acid aldolase". Carbohydrate Metabolism. Methods in Enzymology. Vol. 9. pp. 524–528. doi:10.1016/0076-6879(66)09104-3. ISBN 978-0-12-181809-8.